The major findings of the project were:

Basic Discovery genetics and bio-statistical modelling:

• The largest study of severe asthma genomics,
• The largest study of COPD airway transcriptome
• The first study of genomics and trait analyses in severe asthma for inflammation and CT-determined airway remodelling

Clinical trials and computational modelling:

• The first study to demonstrate efficacy of anti-DP2 upon airway inflammation and remodelling
• The first computational model of eosinophilic airway inflammation and remodelling
• The first computational model of thermoplasty validated by a clinical trial in severe asthma

Computational models of airway physiology

• First computational models of oscillometry, multiple breath washout and spirometry open access through CHASTE

Functional Respiratory imaging

• Development of a new work flow to enable high throughput 3D mesh generation from CT scans and computational fluid dynamics to inform our understanding of heterogeneity of airways disease and response to therapy

Commercialisation

• New CT segmentation software
• Advanced functional respiratory imaging
• Software for multiple-breath washout analysis
• Suite of computational tools to enhance early development