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Participants

Participants

Please note: Recruitment for the project has now ended. 

 

For the results to be scientifically reliable, a large number of volunteers were needed. People with and without asthma volunteered to take part in the project, providing samples and other information about their general health and asthma. Volunteers gave blood, urine and sputum samples and were asked, but not required, to give a lung tissue sample collected during bronchoscopy.

Groups

A total of 1,025 volunteers have been recruited, making U-BIOPRED one of the largest projects of its kind. There are 726 adults and 299 children being studied. The volunteers are divided into 5 different groups, knowen as cohorts, so that the scientists can compare the characteristics of the groups and learn more about each type.

Adults

Cohort A: Severe asthma (18 years or over): uncontrolled asthma symptoms (according to GINA (Global Initiative for Asthma) guidelines) or frequent severe exacerbations despite high dose inhaled cortico-steroids (ICS) plus at least one other controller therapy.  Non or ex-smokers.

Cohort B: Severe asthma (18 years or over): uncontrolled asthma symptoms (according to GINA (Global Initiative for Asthma) guidelines) or frequent severe exacerbations despite high dose ICS plus at least one other controller therapy. Current smokers.

Cohort C: Mild-moderate asthma (18 years or over): controlled or partially controlled asthma symptoms (according to GINA guidelines) with the prescription of low to moderate dose ICS.
Non smokers.

Cohort D: COPD (18 years or over): current and ex smokers prescribed ICS fulfilling the GOLD (Global Initiative for Obstructive Lung Disease) diagnostic criteria for COPD.

Cohort E: Healthy controls (18 years or over): non-asthmatic healthy individuals free of significant disease.  Non smokers.

Measurements to be undertaken:

Children

Cohort A: Severe school aged asthma (6-17 years): persistent symptoms or frequent severe exacerbations or persistent airflow limitation despite the prescription of high dose ICS or prescription of maintenance oral corticosteroids (OCS).

Cohort B: Mild-moderate school aged asthma (6-17 years): controlled asthma symptoms (according to GINA guidelines) with the prescription of low to moderate dose ICS.

Cohort C: Severe pre-school wheeze (1-5 years): persistent symptoms or frequent severe exacerbations despite the prescription of high dose ICS (or failed trial) or prescription of maintenance OCS.

Cohort D: Mild-moderate pre-school wheeze (1-5 years): controlled symptoms (according to GINA guidelines) with the prescription of low to moderate dose ICS.

Measurements to be undertaken: